CD146 Antibody / MCAM / MUC18
The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. CD146 expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. It is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
Product Specifications
UniProt
P43121
Host
Mouse
Immunogen
Recombinant human protein was used as the immunogen for the CD146 antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Applications
FACS, IF, IHC-P
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the CD146 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD146 antibody is available for research use only.
CAS Number
9007-83-4
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