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Fas Antibody / CD95

MAb B-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycosidic-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro) . CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry: 1-2 µg/mL, Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-3 µg/mL

UniProt

P25445

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human protein was used as the immunogen for the Fas antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

B-R18

Applications

IHC, FACS, IF

Purity

Protein G affinity chromatography

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Reconstitution

Store the Fas antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Limitations

This Fas antibody is available for research use only.

Storage Conditions

Store the Fas antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide

Applications Notes

Optimal dilution of the Fas antibody should be determined by the researcher.

Location

Cytoplasmic, membranous

Image Legend

SDS-PAGE Analysis of Purified, BSA-Free Fas Antibody (B-R18) . Confirmation of Integrity and Purity of the Antibody.

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