CD11b Antibody / MAC-1
CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin alpha-M (CD11b) combines with the Integrin beta-2 (CD18) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin alpha-M/beta-2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.
Product Specifications
Host
Rat
Immunogen
B10 mouse spleen cells enriched for T lymphocytes were used as the immunogen for this CD11b antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Applications
FACS, IF, Functional studies
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CD11b antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD11b antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6693867/datasheet/v2161-20ug.pdf
CAS Number
9007-83-4
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