CARM1-IN-5
CARM1-IN-5 (Compound 17e) is a potent and selective inhibitor of CARM1 (IC50= 2 nM) . CARM1-IN-5 effectively prevents CARM1 from methylating substrate proteins by directly interacting with CARM1. CARM1-IN-5 exhibits significant antiproliferative effects on melanoma cell lines[1].
Product Specifications
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/carm1-in-5.html
Solubility
10 mM in DMSO
Smiles
CN(CC1=CC=CC=C1OCC2=CC(Cl)=C(C=C2)C3=NC=CS3)C[C@H](CNC)O
Molecular Formula
C22H26ClN3O2S
Molecular Weight
431.98
References & Citations
[1]Liu Z, et al. Development of (2- (Benzyloxy) phenyl) methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma. J Med Chem. 2024 Apr 25;67 (8) :6313-6326.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
