CARM1-IN-5

CARM1-IN-5 (Compound 17e) is a potent and selective inhibitor of CARM1 (IC50= 2 nM) . CARM1-IN-5 effectively prevents CARM1 from methylating substrate proteins by directly interacting with CARM1. CARM1-IN-5 exhibits significant antiproliferative effects on melanoma cell lines[1].

Product Specifications

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/carm1-in-5.html

Solubility

10 mM in DMSO

Smiles

CN(CC1=CC=CC=C1OCC2=CC(Cl)=C(C=C2)C3=NC=CS3)C[C@H](CNC)O

Molecular Formula

C22H26ClN3O2S

Molecular Weight

431.98

References & Citations

[1]Liu Z, et al. Development of (2- (Benzyloxy) phenyl) methanamine Derivatives as Potent and Selective Inhibitors of CARM1 for the Treatment of Melanoma. J Med Chem. 2024 Apr 25;67 (8) :6313-6326.