EIF3e Antibody
Eukaryotic translation initiation factor 3 subunit E is a protein that in humans is encoded by the EIF3E gene. The human homolog of EIF3E is located on chromosome region 8q22-q23. It is composed of 13 exons that span 45 kb of genomic DNA. EIF3E is the component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis ts localization/assembly. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). And the eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Product Specifications
UniProt
P60228
Host
Rabbit
Immunogen
Amino acids A160-Q241 from the human protein were used as the immunogen for the EIF3e antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Format
Antigen affinity purified
Buffer
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Reconstitution
Limitations
This EIF3e antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6687968/datasheet/r32741.pdf
CAS Number
9007-83-4
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