AAMP Antibody

Angio-associated migratory cell protein is in humans is encoded by the AAMP gene. It is mapped to 2q35. AAMP is an immunoglobulin-type protein which is found to be expressed strongly in endothelial cells, cytotrophoblasts, and poorly differentiated colon adenocarcinoma cells found in lymphatics. It has been demonstrated that an AAMP peptide containing the putative heparan sulfate-binding domain binds to heparin and mediates heparin-sensitive cell adhesion. It plays a role in angiogenesis and cell migration. In smooth muscle cell migration, it may act through the RhoA pathway.