Cdk2 Antibody

Cyclin-Dependent Kinase 2 is also know as p33. The protein is highly homologous to p34 (CDC2) kinase and more significantly homologous to Xenopus Eg1 kinase, suggesting that<a href=../search_result.php?search_txt=cdk2>Cdk2</a>is the human homolog of Eg1. The gene is mapped to 12q13, the same region to which the<a href=../search_result.php?search_txt=cdk4>Cdk4</a>gene maps. Human Cyclin A binds independently to two kinases, p34/Cdc2) or p33/Cdk2. In adenovirus-transformed cells, the viral E1A oncoprotein seems to associate with p33/Cyclin A but not with p34(cdc2)/cyclin A. The gene for p33 shares 65% sequence identity with p34(cdc2). Cdk2 plays a unique role in cell cycle regulation of vertebrate cells.