DUSP10 Antibody
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. The protein is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli.
Product Specifications
UniProt
Q9Y6W6
Host
Rabbit
Immunogen
A portion of amino acids 1-30 from the human protein was used as the immunogen for the Dual specificity protein phosphatase 10 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC-P, WB
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Dual specificity protein phosphatase 10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Dual specificity protein phosphatase 10 antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6685176/datasheet/f54969-0.4ml.pdf
CAS Number
9007-83-4
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