NR1I2 Antibody / PXR
NR1I2/PXR belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. This protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin.
Product Specifications
UniProt
O75469
Host
Rabbit
Immunogen
A portion of amino acids 100-127 from the human protein was used as the immunogen for the PXR antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IF, FACS, IHC-P, WB
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the PXR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PXR antibody is available for research use only.
CAS Number
9007-83-4
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