LYK5 Antibody / STRADA
LYK5, also STE20-related Adaptor Protein (STRAD) are members of STE-20 like kinase family that are known to stimulate MAPK pathways by directly activating MAPKKK. LYK5 is a novel pseudokinase member of this family consisting of a STE-20 like kinase domain but lacks several residues that are required for its catalytic activity. It specifically binds LKB1 and plays a key role in regulating tumor suppressor activities of LKB1. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRAD-LKB1 interaction results in phosphorylation of STRAD and enhanced autophosphorylation of LKB1.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:500-1:2000, Flow cytometry: 1:25 (1x10e6 cells), Immunofluorescence: 1:25
UniProt
Q7RTN6
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 12-41 from the human protein was used as the immunogen for the LYK5 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, FACS, IF
Purity
Antigen affinity purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the LYK5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This LYK5 antibody is available for research use only.
Storage Conditions
Aliquot the LYK5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.nsjbio.com/tds-pdf/lyk5-antibody-strada-f54440
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Location
Nuclear, cytoplasmic
Image Legend
Western blot testing of human 1) U-2 OS, 2) SH-SY5Y and 3) MOLT4 cell lysate with LYK5 antibody. Predicted molecular weight ~48 kDa.
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