Thymidylate Synthase Antibody
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.
Product Specifications
UniProt
P04818
Host
Rabbit
Immunogen
A portion of amino acids 265-294 from the human protein was used as the immunogen for the Thymidylate Synthase Antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC-P, IF, FACS
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Thymidylate Synthase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Thymidylate Synthase antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6683895/datasheet/f54315-0.4ml.pdf
CAS Number
9007-83-4
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