SUZ12 Antibody

Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1:2000

UniProt

Q15022

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This SUZ12 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 375-408 amino acids from the Central region of human SUZ12.

Clonality

Polyclonal

Isotype

Applications

WB, ELISA

Purity

Antigen affinity

Format

Antigen affinity purified

Buffer

In 1X PBS, pH 7.4, with 0.09% sodium azide

Reconstitution

Aliquot the SUZ12 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This SUZ12 antibody is available for research use only.

Storage Conditions

Aliquot the SUZ12 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

In 1X PBS, pH 7.4, with 0.09% sodium azide

Applications Notes

Titration of the SUZ12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Image Legend

Western blot testing of SUZ12 antibody at 1:2000 dilution. Lane 1: mouse spleen lysate; 2: F9 lysate; 3: HeLa lysate; Observed molecular weight 83~95 kDa.