Hopx Antibody
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1:2000
UniProt
Q8R1H0
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Hopx antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Hopx antibody is available for research use only.
Storage Conditions
Aliquot the Hopx antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Hopx antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of Hopx antibody at 1:2000 with 1) human heart lysate and 2) mouse heart lysate
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