Mavs Antibody (Ips-1)
Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis (By similarity).
Product Specifications
UniProt
Q8VCF0
Host
Rabbit
Immunogen
A portion of amino acids 1-30 from the mouse protein was used as the immunogen for this Ips-1 antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Ips-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Ips-1 antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6680647/datasheet/f47745-0.08ml.pdf
CAS Number
9007-83-4
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