Aurora-B Antibody (Aurkb)
Aurkb may be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1 (By similarity).
Product Specifications
UniProt
O70126
Host
Rabbit
Immunogen
A portion of amino acids 84-111 from the mouse protein was used as the immunogen for this Aurkb antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, ELISA
Format
Antigen affinity purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Aurkb antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Aurkb antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6680093/datasheet/f44415-0.08ml.pdf
CAS Number
9007-83-4
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