ES-8891
Product Specifications
UNSPSC Description
ES-8891 is a renin inhibitor. Oral administration of ES-8891 to normotensive sodium-depleted macaques for one week significantly reduced plasma renin activity, immunoreactive renin concentrations, and plasma angiotensin I concentrations, while mean blood pressure decreased significantly, without significant changes in heart rate. ES-8891 regulates blood pressure by inhibiting plasma renin levels and renal renin synthesis[1].
Target Antigen
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/es-8891.html
Smiles
O=C(NCCCCCC)C[C@H](O)[C@@H](NC([C@@H](NC([C@@H](NC(CN1CCOCC1)=O)CC2=C3C=CC=CC3=CC=C2)=O)CC4=CSC=N4)=O)CC5CCCCC5
Molecular Weight
777.03
References & Citations
[1]YUTAKA KITAMI, KUNIO HIWADA, EIKI MURAKAMI, TAKERU IWATA, SHINJIRO MUNETA AND TATSUO KOKUBU"
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117913/ES-8891-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117913/
Clinical Information
No Development Reported
CAS Number
129445-88-1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Monoclonal Cbx2 Antibody (RAB-C238) [HRP] - Chimeric](https://cdn.genprice.uk/genprice/genprice3.png)
MBS6356754-01 0.1 mL
TMPRSS6, NT (TMPRSS6, Transmembrane protease serine 6, Matriptase-2) (MaxLight 650)
Ask
View Details MBS6356754-02 5x 0.1 mL
TMPRSS6, NT (TMPRSS6, Transmembrane protease serine 6, Matriptase-2) (MaxLight 650)
Ask
View Details 