SET07 Antibody
SET07 is a protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. [UniProt]
Product Specifications
UniProt
Q9NQR1
Host
Mouse
Immunogen
This SET07 antibody was raised using purified recombinant GST fusion protein encoding N-terminal of human SET07.
Clonality
Monoclonal
Isotype
IgG1
Applications
WB, ELISA
Format
Purified
Buffer
In 1X PBS pH 7.4 with 0.09% sodium azide
Reconstitution
Aliquot the SET07 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This SET07 antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/6678852/datasheet/f40199-0.08ml.pdf
CAS Number
9007-83-4
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