PPZ2
Product Specifications
UNSPSC Description
PPZ2 is a diacylglycerol (DAG)-activated TRPC3/TRPC6/TRPC7 channel activator with activity in promoting neuronal development and survival. PPZ2 activates recombinant TRPC3/TRPC6/TRPC7 channels in a dose-dependent manner without affecting other TRPC channels. PPZ2 elicits cation currents and calcium ion (Ca(2+)) influx in cultured central neurons. PPZ2 is able to induce BDNF-like neurite outgrowth and neuroprotection, an effect that disappears after TRPC3/TRPC6/TRPC7 knockdown or inhibition. PPZ2 also increases the activation of the calcium-dependent transcription factor cAMP response element binding protein. The effects of PPZ2 suggest that calcium signaling mediated by activation of DAG-activated TRPC channels plays an important role in its neurotrophic effects[1].
Target Antigen
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ppz2.html
Smiles
O=C(NC1=CC=CC=C1OCC)CN2CCN(C3=CC=CC(C)=C3C)CC2
Molecular Weight
367.48
References & Citations
[1]Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111527/PPZ2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111527/
Clinical Information
No Development Reported
CAS Number
896203-18-2
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1040049-01 0.05 mg (E-Coli)
Recombinant Pseudomonas stutzeri Ferrochelatase (hemH)
Ask
View Details MBS1040049-02 0.05 mg (Yeast)
Recombinant Pseudomonas stutzeri Ferrochelatase (hemH)
Ask
View Details 
MBS1040049-03 0.2 mg (E-Coli)
Recombinant Pseudomonas stutzeri Ferrochelatase (hemH)
Ask
View Details 
MBS1040049-04 0.05 mg (Baculovirus)
Recombinant Pseudomonas stutzeri Ferrochelatase (hemH)
Ask
View Details MBS1040049-05 0.5 mg (E-Coli)
Recombinant Pseudomonas stutzeri Ferrochelatase (hemH)
Ask
View Details 
MBS1040049-06 0.2 mg (Yeast)
Recombinant Pseudomonas stutzeri Ferrochelatase (hemH)
Ask
View Details