Sulfoxaflor

Sulfoxaflor is an orally active full agonist of insect nicotinic acetylcholine receptors (nAChRs), targeting the α-bungarotoxin-insensitive nAChR1 and nAChR2 subtypes. Sulfoxaflor binding to nACh is not inhibited by d-Tubocurarine (HY-125901), but is partially inhibited by Mecamylamine (HY-B1395A) . Sulfoxaflor induces inward currents by activating nAChRs, leading to insect neurotoxicity. Sulfoxaflor can be used in the research of agricultural pest control, pesticide toxicology, insect neural receptor pharmacology, etc[1][2].

Product Specifications

CAS Number

[946578-00-3]

Product Name Alternative

PCR 5332

UNSPSC

12352005

Hazard Statement

H302, H400, H410

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sulfoxaflor.html

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C1=CC=C(C(F)(F)F)N=C1)S(=NC#N)(C)=O

Molecular Formula

C10H10F3N3OS

Molecular Weight

277.27

Precautions

H302, H400, H410

References & Citations

[1]Jean-Noël Houchat, et al. Mode of Action of Sulfoxaflor on α-bungarotoxin-insensitive nAChR1 and nAChR2 Subtypes: Inhibitory Effect of Imidacloprid. Neurotoxicology. 2019 Sep;74:132-138.|[2]Siviter H, et al. Sulfoxaflor exposure reduces bumblebee reproductive success. Nature. 2018 Sep;561 (7721) :109-112.