BL-1020 (mesylate)

BL-1020 mesylate is the mesylate salt form of BL-1020. BL-1020 mesylate is an antipsychotic agent. BL-1020 mesylate is inhibitor for dopamine receptor and serotonin receptor (5-HT receptor), with Ki of 0.066, 0.062 and 0.21 nM, for D2L, D2S and 5-HT2A receptors, respectively. BL-1020 mesylate is agonist for GABAA receptor with Ki of 3.74 μM, and enhances the GABA release. BL-1020 mesylate exhibits high affinity with histamine receptor (Ki is 0.47 nM) . BL-1020 mesylate reduces Amphetamine-induced hyperactivity, with lower catalepsy and sedation. BL-1020 mesylate is blood-brain barrier penetrate[1].

Product Specifications

CAS Number

[916898-61-8]

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor; GABA Receptor; Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bl-1020-mesylate.html

Smiles

O=C(CCCN)OCCN1CCN(CCCN2C3=C(SC4=CC=C(C=C42)Cl)C=CC=C3)CC1.O=S(O)(C)=O

Molecular Formula

C26H37ClN4O5S2

Molecular Weight

585.18

References & Citations

[1]Geffen Y, et al., BL-1020: a novel antipsychotic drug with GABAergic activity and low catalepsy, is efficacious in a rat model of schizophrenia. Eur Neuropsychopharmacol. 2009 Jan;19 (1) :1-13.