Pachypodol

Pachypodol is an orally active methoxyflavonoid compound. Pachypodol activates the ERK-dependent Nrf2 pathway and inhibits Apoptosis. Pachypodol exhibits activities such as antioxidant, cytoprotective, anti-inflammatory effects. Pachypodol improves cognition. Pachypodol exerts protective effects against cardiac and liver damage. Pachypodol has anticancer activity against colon cancer[1][2][3][4][5].

Product Specifications

CAS Number

[33708-72-4]

UNSPSC

12352005

Target

Apoptosis; Keap1-Nrf2; PERK

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pachypodol.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(OC)=C(C2=CC(OC)=C(O)C=C2)OC3=CC(OC)=CC(O)=C13

Molecular Formula

C18H16O7

Molecular Weight

344.32

References & Citations

[1]Kim EK, et al. Pachypodol, a Methoxyflavonoid Isolated from Pogostemon cablin Bentham Exerts Antioxidant and Cytoprotective Effects in HepG2 Cells: Possible Role of ERK-Dependent Nrf2 Activation. Int J Mol Sci. 2019;20 (17) :4082. Published 2019 Aug 21.|[2]Ali HA, et al. Pachypodol, a flavonol from the leaves of Calycopteris floribunda, inhibits the growth of CaCo 2 colon cancer cell line in vitro. Phytother Res. 2008;22 (12) :1684-1687. |[3]Zahara S S, et al. Pachypodol attenuates arsenic triggered cardiac damage via rectifying oxidative stress, inflammation, apoptosis and histopathological alterations. Journal of King Saud University-Science, 2024, 36 (7) : 103260.|[4]Zhang J, et al. Pachypodol protects newborn rats from anaesthesia-induced apoptosis in the developing brain by regulating the JNK/ERK pathway. Int J Dev Neurosci. 2021 Nov;81 (7) :633-642.|[5]Ijaz M U, et al. Pachypodol, a Plant Flavonoid, Mitigates Cisplatin-Induced Hepatotoxicity Through Anti-Oxidant, Anti-Inflammatory and Anti-Apoptotic Mechanisms. J. Food Nutr. Res., 2023, 11: 513-518.