GRGDSPK

GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD) . GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption[1][2].

Product Specifications

CAS Number

[111119-28-9]

Product Name Alternative

EMD 56574

UNSPSC

12352209

Hazard Statement

H302-H315-H319

Target

Integrin

Type

Peptides

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/GRGDSPK.html

Purity

98.12

Solubility

H2O

Smiles

O=C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)CN

Molecular Formula

C28H49N11O11

Molecular Weight

715.76

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Sessions BR, et al. Effects of amino acid substitutions in and around the arginine-glycine-aspartic acid (RGD) sequence on fertilization and parthenogenetic development in mature bovine oocytes. Mol Reprod Dev. 2006 May;73 (5) :651-7.|[2]G A Gronowicz, et al. Synthetic Peptide Containing Arg-Gly-Asp Inhibits Bone Formation and Resorption in a Mineralizing Organ Culture System of Fetal Rat Parietal Bones. J Bone Miner Res. 1994 Feb;9 (2) :193-201.|[3]Pierre-Henri Puech, et al. Measuring Cell Adhesion Forces of Primary Gastrulating Cells From Zebrafish Using Atomic Force Microscopy. J Cell Sci. 2005 Sep 15;118 (Pt 18) :4199-206.