LT175

LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ (hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm) . LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1) . LT175 interacts with PPARγ in a hydrophobic region called "diphenyl pocket" . LT175 has potent insulin-sensitizing effects and reduced adipogenic properties[1].

Product Specifications

CAS Number

[862901-87-9]

UNSPSC

12352005

Hazard Statement

H301-H312-H330-H410

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/lt175.html

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](OC1=CC=C(C2=CC=CC=C2)C=C1)CC3=CC=CC=C3)O

Molecular Formula

C21H18O3

Molecular Weight

318.37

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Federica Gilardi, et al. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. J Biol Chem. 2014 Mar 7;289 (10) :6908-6920.