BIM5078

BIM5078 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BIM5078 represses insulin promoter activity through HNF4α antagonism. BIM5078 can be used for the research of cancer and diabetes[1].

Product Specifications

CAS Number

[337506-43-1]

UNSPSC

12352005

Hazard Statement

H301

Target

Nuclear Hormone Receptor 4A/NR4A

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/bim5078.html

Solubility

10 mM in DMSO

Smiles

[O-][N+](C1=CC=C(C(S(=O)(N2C3=C(N=C2C)C=CC=C3)=O)=C1)Cl)=O

Molecular Formula

C14H10ClN3O4S

Molecular Weight

351.76

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Kiselyuk A, et al. HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27;19 (7) :806-18.