Prostaglandin E2 Ethanolamide
Product Specifications
UNSPSC Description
Prostaglandin E2 Ethanolamide (PGE2-EA), an analog of PGE2, can be formed enzymatically following COX-2 oxygenation of endocannabinoids. Prostaglandin E2 Ethanolamide (PGE2-EA) could modulate the production of the proinflammatory cytokine TNF-α in human blood and human monocytic cells[1][2].
Target Antigen
COX; Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/prostaglandin-e2-ethanolamide.html
Solubility
10 mM in DMSO
Smiles
CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C\CCCC(NCCO)=O
Molecular Weight
395.53
References & Citations
[1]Kevin R Kozak, et al. Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J Biol Chem. 2002 Nov 22;277(47):44877-85.|[2]Kirsten L Brown, et al. Characterisation of the prostaglandin E2-ethanolamide suppression of tumour necrosis factor-α production in human monocytic cells. Biochim Biophys Acta. 2013 Jun;1831(6):1098-107.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121996/Prostaglandin-E2-Ethanolamide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121996/
Clinical Information
No Development Reported
CAS Number
194935-38-1
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