L-2-Hydroxyglutaric acid
Product Specifications
UNSPSC Description
L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].
Target Antigen
Endogenous Metabolite; Histone Demethylase; Mitochondrial Metabolism
Type
Natural Products
Related Pathways
Epigenetics;Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/L-2-Hydroxyglutaric_acid.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@@H](O)CCC(O)=O
Molecular Weight
148.11
References & Citations
[1]Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4(11):1290-8.|[2]da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21(4):217-24.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113039/L-2-Hydroxyglutaric-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113039/L-2-Hydroxyglutaric-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
13095-48-2
Available Sizes
Curated Selection
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