Pan-RAS-IN-6
Product Specifications
UNSPSC Description
Pan-RAS-IN-6 (compound 24) is an inhibitor targeting DUSP6, which reduces MAPK activation in the brain of the NCI-H1373-Luc model (DUSP6), at the same time, it shows significant tumor growth inhibition and tumor regression effects in the NSCLC brain metastasis mouse model. Pan-RAS-IN-6 shows high selectivity and strong inhibitory effects, especially in KRAS mutation-related signaling pathways, demonstrating varying inhibitory activity against different KRAS mutants and interacting proteins. The IC50 values for KRAS G12C, G12D, and G12V are 1.3 nM, 4.7 nM, and 0.3 nM, respectively[1].
Target Antigen
Phosphatase; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway;Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dusp6-in-1.html
Smiles
O=C(OCC(C)(C)CC1=[C@@]([C@@]2=C([C@@H](OC)C)N=CC(N3CCN(C)CC3)=C2)N4C5=C1C=C6C=C5CCC4)[C@H]7NN(C([C@@H](NC([C@H]8[C@H](C)[C@@H]8C)=O)CC9=NC6=CS9)=O)CCC7
Molecular Weight
837.08
References & Citations
[1]Jianguo Chen, et al. Design, Tricyclic compounds for the treatment of cancer. WO2024169914A1. 2024-02-08
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168012/Pan-RAS-IN-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168012/
Clinical Information
No Development Reported
Curated Selection
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