PHF6
PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein[1].
Product Specifications
CAS Number
[329897-62-3]
UNSPSC
12352209
Target
Amyloid-β; Autophagy
Type
Peptides
Related Pathways
Autophagy; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/phf6.html
Purity
99.17
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1C[C@@H](C(N[C@H](C(O)=O)CCCCN)=O)NC([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@@H](N)C(C)C)=O)=O)=O)=O
Molecular Formula
C36H60N8O9
Molecular Weight
748.91
References & Citations
[1]Chinmaya Panda, et al. Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells. Cell. 2021 Jun 30;10 (7) :1652.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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