Phenyltoloxamine
Product Specifications
UNSPSC Description
Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (Ki: 160 nM)[1][2][3].
Target Antigen
Cytochrome P450; Histamine Receptor; Sigma Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/phenyltoloxamine.html
Solubility
10 mM in DMSO
Smiles
CN(C)CCOC1=CC=CC=C1CC2=CC=CC=C2
Molecular Weight
255.35
References & Citations
[1]Justin B.Hoekstra. Pharmacological Properties of a New Antihistaminic Agent, Phenyltoloxamine (Bristamin). Journal of the American Pharmaceutical Association (Scientific ed.). 1953, 42 (10), 587-593. |[2]Brandes LJ, et al. Evidence that the antiestrogen binding site is a histamine or histamine-like receptor. Biochem Biophys Res Commun. 1985 Jan 31;126(2):905-10. |[3]Youyi Peng, et al. Comprehensive 3D-QSAR Model Predicts Binding Affinity of Structurally Diverse Sigma 1 Receptor Ligands. J Chem Inf Model. 2019 Jan 28;59(1):486-497. |[4]Sellers, et al. Use of inhibitors of CYP2D6 enzyme for the prevention of drug abuse. Patent, US6124282.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B1733/Phenyltoloxamine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B1733/
Clinical Information
Launched
CAS Number
92-12-6
Curated Selection
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