Triptoquinone B

Triptoquinone B ((+) -Triptoquinone B), a sesquiterpene alkaloid, is an interleukin-1 inhibitor. Triptoquinone B shows potent inhibitory activities against interleukin 1α and β releases for human peripheral mononuclear cells[1][2].

Product Specifications

CAS Number

[142937-50-6]

Product Name Alternative

(+) -Triptoquinone B

UNSPSC

12352211

Target

Interleukin Related

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/triptoquinone-b.html

Solubility

10 mM in DMSO

Smiles

O=C1C(C(C)C)=CC(C([C@@]2(C)CC3)=C1CC[C@@]2([H])[C@@](C)(CO)C3=O)=O

Molecular Formula

C20H26O4

Molecular Weight

330.42

References & Citations

[1]Takaishi Y, et, al. Triptoquinone A and B novel interleukin-1 inhibitors from Tripterygium wilfordii var Regeli. Tetrahedron Letters. 1992 Nov; 33 (47) : 7177-7180.|[2]Wang XD, et, al. Terpene alkaloids from Tripterygium wilfordii. J Asian Nat Prod Res. 2005 Oct;7 (5) :755-9.