CD273 Recombinant Protein
Product Specifications
Background
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
CAS Number
9000-83-3
NCBI Gene ID
80380
Swiss Prot
Q9BQ51
Accession Number
AAI13679
Tag
C-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Apoptosis, Immunology
Purity
>95% as determined by SDS-PAGE more than 90% measured by SEC-HPLC.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
49.2 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Programmed cell death 1 ligand 2
NCBI Organism
Homo sapiens
Background Reference 01
Tseng S.-Y., et al., 2001, J. Exp. Med. 193:839-846.
Background Reference 02
Latchman Y., et al., 2001, Nat. Immunol. 2:261-268.
Background Reference 03
He X.-H., et al., 2004, Acta Biochim. Biophys. Sin. 36:284-289.
Other Product Names
PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
Curated Selection
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