PLGF / PGF (19-221) Recombinant Protein
Product Specifications
Background
Placental growth factor (PGF) is also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
CAS Number
9000-83-3
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Growth Factors, Obesity, Signal Transduction
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-159
Calculated Molecular Weight
49.2 kDa
Applications Notes
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.2 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background Reference 01
Maglione D., et al., 1993, Oncogene 8 (4) : 925–31.
Background Reference 02
Khalil A., et al., 2008, PLoS ONE 3 (7) : e2766.
Background Reference 03
Khurana R., et al., 2005, Circulation 111 (21) : 2828–2836.
Background Reference 04
Rolny C., et al., 2011, Cancer Cell 19:31-44.
Other Product Names
PGF, PLGF, PlGF, PGFL, SHGC-10760
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
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