IL-36Ra Recombinant Protein
Product Specifications
Background
IL-36Ra/IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) . These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are target of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
NCBI Gene ID
26525
Swiss Prot
O15123
Accession Number
Q9UBH0
Tag
Tag Free
Type
Recombinant Proteins
Source
E. coli
Field of Research
Immunology
Concentration
0.1mg/ml after reconstitution.
Buffer
Contains PBS. Reconstitute with 100 μ l sterile water.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=90-281
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Interleukin 36 receptor antagonist
NCBI Organism
Homo sapiens
Other Product Names
Interleukin-36 Receptor Antagonist Protein, IL-1F5, Interleukin-1 Family Member 5, IL-1delta, Interleukin-1delta Interleukin-1 Homolog 3, Interleukin-1-like Protein 1
Species
Human
Protein ID
27894310
Physical Properties
Lyophilized
CAS Number
9000-83-3
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