CD24 Recombinant Protein

Product Specifications

Background

CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.

CAS Number

9000-83-3

NCBI Gene ID

100133941

Swiss Prot

P25063

Accession Number

NP_001278666.1

Tag

Mouse IgG Fc Tag

Type

Recombinant Proteins

Source

HEK293 cells

Field of Research

Signal Transduction, Stem Cell, Other

Purity

>90% as determined by SDS-PAGE.

Buffer

50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5

Shipping Conditions

Room Temp

Storage Conditions

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

30.0 kDa

Applications Notes

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 30.0 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.