BMP-2 Recombinant Protein
Product Specifications
Background
Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB) . BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.
CAS Number
9000-83-3
NCBI Gene ID
650
Swiss Prot
P09793
Accession Number
NP_001191
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Cell Cycle, Growth Factors, Signal Transduction, Stem Cell
Buffer
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=90-374
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Bone morphogenetic protein 2
NCBI Organism
Homo sapiens
Other Product Names
BMP2, Bone Morphogenetic Protein 2
Species
Human
Protein ID
4557369
Physical Properties
Lyophilized
Curated Selection
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