PFKFB1 Recombinant Protein

Product Specifications

Background

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. It belongs to the phosphoglycerate mutase family. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.

CAS Number

9000-83-3

NCBI Gene ID

5207

Swiss Prot

P16118

Accession Number

P16118

Tag

C-6 His tag

Type

Recombinant Proteins

Source

Human Cells

Field of Research

Cancer, Neuroscience, Obesity, Signal Transduction

Buffer

Supplied as a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

Shipping Conditions

Dry Ice

Calculated Molecular Weight

55.6 kD

Applications Notes

This recombinant protein can be used for biological assays. For research use only.

NCBI Official Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

NCBI Organism

Homo sapiens

Other Product Names

6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1, 6PF-2-K/Fru-2, 6-P2ase liver isozyme, Fructose-2, 6-bisphosphatase, PFKFB1, F6PK, PFRX, PFK, FBPase 1