Tryptamine

Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM) . Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs) and accelerates gastrointestinal motility. Tryptamine regulates Th17/Treg balance to inhibit neuroinflammation, competitively binds to 5-HT receptors to regulate central nervous system activity, and participates in temperature regulation and spinal reflex regulation as a neuromodulator. Tryptamine can be used to study intestinal motility disorders such as functional constipation, and has shown significant efficacy in multiple sclerosis models[1][2][3].

Product Specifications

CAS Number

[61-54-1]

Product Name Alternative

3- (2-Aminoethyl) indole~2- (3-Indolyl) ethylamine

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H335

Target

5-HT Receptor; Aryl Hydrocarbon Receptor; Endogenous Metabolite

Type

Natural Products

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Tryptamine.html

Purity

99.95

Solubility

DMSO : ≥ 150 mg/mL

Smiles

NCCC1=CNC2=C1C=CC=C2

Molecular Formula

C10H12N2

Molecular Weight

160.22

Precautions

H302, H315, H318, H335

References & Citations

[1]Jones RS, et al. Tryptamine: a neuromodulator or neurotransmitter in mammalian brain? Prog Neurobiol. 1982;19 (1-2) :117-39.|[2]Dopkins N, et al. Tryptamine Attenuates Experimental Multiple Sclerosis Through Activation of Aryl Hydrocarbon Receptor. Front Pharmacol. 2021 Jan 25;11:619265.|[3]Bhattarai Y, et al. Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion. Cell Host Microbe. 2018 Jun 13;23 (6) :775-785.e5.