Sacubitril-d5 (hemicalcium)

Sacubitril-d5 (AHU-377-d5) hemicalcium is deuterium-labeled Sacubitril hemicalcium (HY-15407A) [1].

Product Specifications

Product Name Alternative

AHU-377-d5 (hemicalcium)

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Neprilysin

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

O=C(CCC([O-])=O)N[C@H](CC1=CC=C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C=C1)C[C@@H](C)C(OCC)=O.[0.5Ca2+]

Molecular Formula

C24H24D5NO5.1/2Ca

Molecular Weight

435.55

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Smith K A, et al. Soil and environmental analysis[M]. Marcel Dekker Incorporated, 2000.|[3]Fan T W M, et al. Stable isotope-resolved metabolomics and applications for drug development[J]. Pharmacology & therapeutics, 2012, 133 (3) : 366-391.