Rotundic acid

Rotundic acid, a triterpenoid obtained from Ilex rotunda Thunb., induces DNA damage and cell apoptosis in hepatocellular carcinoma through AKT/mTOR and MAPK Pathways. Rotundic acid possesses anti-inflammatory and cardio-protective abilities[1].

Product Specifications

CAS Number

[20137-37-5]

UNSPSC

12352211

Target

Akt; Apoptosis; mTOR; p38 MAPK

Type

Natural Products

Related Pathways

Apoptosis; MAPK/ERK Pathway; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/rotundic-acid.html

Purity

99.41

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]1(CO)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@](C)(O)[C@H](C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]

Molecular Formula

C30H48O5

Molecular Weight

488.70

References & Citations

[1]Roy G, et al. Rotundic Acid Induces DNA Damage and Cell Death in Hepatocellular Carcinoma Through AKT/mTOR and MAPK Pathways. Front Oncol. 2019 Jun 26;9:545.