TC11

TC11 is a MCL1 degrader and Caspase-9 and CDK1 activator. TC11 functions as a phenylacetylamide derivative and is structurally related to immunomodulatory active molecules. TC11 induces degradation of MCL1 leading to apoptotic death [1][2] during prolonged mitotic arrest.

Product Specifications

CAS Number

[100823-03-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bcl-2 Family; Caspase; CDK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tc11.html

Concentration

10mM

Purity

99.55

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1N(C2=C(C(C)C)C=CC=C2C(C)C)C(C3=C1C=CC(N)=C3)=O

Molecular Formula

C20H22N2O2

Molecular Weight

322.40

Precautions

H302, H315, H319, H335

References & Citations

[1] Ichikawa D, et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochem Biophys Res Commun. 2020;521 (1) :252-258.|[2]Shiheido H, et al. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PLoS One. 2012;7 (6) :e38878.