(E) -2-Hexadecenal

(E) -2-Hexadecenal (trans-2-Hexadecenal) is an MLK3 activator that induces cytoskeletal remodeling, leading to cell rounding, detachment, and ultimately apoptosis in human and mouse cells. (E) -2-Hexadecenal activates the MLK3 signaling pathway, phosphorylating MKK4/7 and JNK, subsequently activating downstream targets of JNK, such as c-Jun phosphorylation, cytochrome c release, Bax activation, Bid cleavage, and Bim translocation to mitochondria. (E) -2-Hexadecenal has potential applications in research related to sphingolipid signaling pathways[1].

Product Specifications

CAS Number

[22644-96-8]

Product Name Alternative

Trans-2-Hexadecenal

UNSPSC

12352211

Target

Apoptosis; JNK; Microtubule/Tubulin; Mixed Lineage Kinase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e-2-hexadecenal.html

Purity

99.9

Smiles

CCCCCCCCCCCCC/C=C/C=O

Molecular Formula

C16H30O

Molecular Weight

238.41

References & Citations

[1]Kumar A, et al. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell Signal. 2011 Jul;23 (7) :1144-52.