Tributyrin

Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed proagent of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects[1].

Product Specifications

CAS Number

[60-01-5]

Product Name Alternative

Glyceryl tributyrate

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Apoptosis; Interleukin Related; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/tributyrin.html

Purity

98.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCC(OCC(OC(CCC)=O)COC(CCC)=O)=O

Molecular Formula

C15H26O6

Molecular Weight

302.36

Precautions

H315, H319, H335

References & Citations

[1]T Gaschott, et al. Tributyrin, a stable and rapidly absorbed prodrug of butyric acid, enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells. J Nutr. 2001 Jun;131 (6) :1839-43.|[2]Claudia P Schröder, et al. Tributyrin-induced differentiation promotes apoptosis of LS 174T colon cancer cells in vitro. Int J Oncol. 2002 Jan;20 (1) :195-200.|[3]Maier S, et al. Tributyrin induces differentiation, growth arrest and apoptosis in androgen-sensitive and androgen-resistant human prostate cancer cell lines. Int J Cancer. 2000 Oct 15;88 (2) :245-51.|[4]Sato FT, et al. Tributyrin Attenuates Metabolic and Inflammatory Changes Associated with Obesity through a GPR109A-Dependent Mechanism. Cells. 2020 Sep 1;9 (9) :2007.|[5]Yang N, et al. Tributyrin alleviates gut microbiota dysbiosis to repair intestinal damage in antibiotic-treated mice. PLoS One. 2023 Jul 31;18 (7) :e0289364.|[6]Vinolo MA, et al. Tributyrin attenuates obesity-associated inflammation and insulin resistance in high-fat-fed mice. Am J Physiol Endocrinol Metab. 2012 Jul 15;303 (2) :E272-82.