RAGE antagonist peptide (TFA)
Product Specifications
UNSPSC Description
RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide TFA prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide TFA possesses anti-tumor and anti-inflammatory activities[1][2].
Target Antigen
Amyloid-β
Type
Peptides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rage-antagonist-peptide-tfa.html
Purity
99.71
Solubility
DMSO : ≥ 50 mg/mL|H2O : 14.29 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)NC(C)=O.O=C(O)C(F)(F)F
Molecular Weight
1386.58
References & Citations
[1]Thiruvengadam Arumugam, et al. S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin Cancer Res. 2012 Aug 15;18(16):4356-64.|[2]Lihong Yao, et al. The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016 Sep;173(17):2600-13.Int J Biol Sci. 2024 Jan 1;20(2):784-800.|Cell Commun Signal. 2023 May 1;21(1):86.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P2268A/RAGE-antagonist-peptide-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P2268A/RAGE-antagonist-peptide-TFA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
EK-046-15 96 Wells
Neurokinin A / Neuromedin L / Substance K (Human, Rat, Mouse) - EIA Kit
Ask
View Details 
BNC741782-100 100 µL
Anti-Thrombomodulin / CD141 (Endothelial Cell Marker) (THBD/1782), CF740 conjugate
Ask
View Details 
MBS2100497-01 5x 96 Tests
Mouse Interleukin 9 Receptor (IL9R) Antibody Pair Kit (with Standard)
Ask
View Details MBS2100497-02 5x 96 Tests + MBS2090685 (Ab Pairs Support Pack 1,5x 96 Tests)
Mouse Interleukin 9 Receptor (IL9R) Antibody Pair Kit (with Standard)
Ask
View Details MBS2100497-03 10x 96 Tests
Mouse Interleukin 9 Receptor (IL9R) Antibody Pair Kit (with Standard)
Ask
View Details