BSB

BSB is a Congo red-derived fluorescent probe. BSB binds not only to extracellular amyloid β protein, but also many intracellular lesions composed of abnormal tau and synuclein proteins. BSB acts as a prototype imaging agent for Alzheimer's disease[1].

Product Specifications

CAS Number

[291766-06-8]

Product Name Alternative

(trans, trans) -1-Bromo-2,5-bis- (3-hydroxycarbonyl-4-hydroxy) styrylbenzene

UNSPSC

12171500

Target

Amyloid-β

Type

Dye Reagents

Related Pathways

Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/bsb.html

Purity

97.24

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

BrC1=CC(/C=C/C2=CC=C(O)C(C(O)=O)=C2)=CC=C1/C=C/C3=CC=C(O)C(C(O)=O)=C3

Molecular Formula

C24H17BrO6

Molecular Weight

481.29

References & Citations

[1]M L Schmidt, et al. The fluorescent Congo red derivative, (trans, trans) -1-bromo-2,5-bis- (3-hydroxycarbonyl-4-hydroxy) styrylbenzene (BSB), labels diverse beta-pleated sheet structures in postmortem human neurodegenerative disease brains. Am J Pathol. 2001 Sep;159 (3) :937-43.