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Cyclo(his-pro)

Product Specifications

UNSPSC Description

Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone[1]. Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses[2].

Target Antigen

Endogenous Metabolite; NF-κB

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease;NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Cyclo_his-pro_.html

Purity

99.41

Solubility

H2O : ≥ 30 mg/mL

Smiles

O=C(N[C@H]1CC2=CN=CN2)[C@@](CCC3)([H])N3C1=O

Molecular Weight

234.25

References & Citations

[1]Grottelli S, et al. The Role of Cyclo(His-Pro) in Neurodegeneration. Int J Mol Sci. 2016 Aug 12;17(8). pii: E1332.|[2]Minelli A, et al. Cyclo(His-Pro) exerts anti-inflammatory effects by modulating NF-κB and Nrf2 signalling. Int J Biochem Cell Biol. 2012 Mar;44(3):525-35.|[3]Bellezza I, et al. Neuroinflammation and endoplasmic reticulum stress are coregulated by cyclo(His-Pro) to prevent LPS neurotoxicity. Int J Biochem Cell Biol. 2014 Jun;51:159-69.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-101402/Cyclo-his-pro-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-101402/Cyclo-his-pro-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

53109-32-3

Available Sizes

Curated Selection

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