Medroxyprogesterone

Medroxyprogesterone (17α-Hydroxy-6α-methylprogesterone) is a synthetic human variant of progesterone that is a progesterone receptor agonist with oral activity. Medroxyprogesterone can induce cell proliferation through the PI3K/Akt signaling pathway. Medroxyprogesterone has an inhibitory effect on atherosclerosis in mice. The progesterone agonist activity of Medroxyprogesterone is less effective than Medroxyprogesterone acetate (HY-B0469) [1][2][3][4].

Product Specifications

CAS Number

[520-85-4]

Product Name Alternative

17α-Hydroxy-6α-methylprogesterone; U8840

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Progesterone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/Medroxyprogesterone.html

Purity

98.82

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@]1([C@@]2(O)C(C)=O)[C@](CC2)([H])[C@@](C[C@H](C)C3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])CC1

Molecular Formula

C22H32O3

Molecular Weight

344.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Saitoh M, et al. Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via phosphatidylinositol 3-kinase/Akt/nuclear factor-kappaB cascade in human breast cancer cells. Endocrinology. 2005 Nov;146 (11) :4917-25.|[2]Ito F, et al. Medroxyprogesterone acetate enhances monocyte-endothelial interaction under flow conditions by stimulating the expression of cell adhesion molecules. J Clin Endocrinol Metab. 2014 Jun;99 (6) :2188-97.|[3] Freudenberger T, et al. Differential effects of medroxyprogesterone acetate on thrombosis and atherosclerosis in mice. Br J Pharmacol. 2009 Dec;158 (8) :1951-60.|[4]Yusop SNW, et al. Medroxyprogesterone derivatives from microbial transformation as anti-proliferative agents and acetylcholineterase inhibitors (combined in vitro and in silico approaches) . Steroids. 2020 Dec;164:108735.