Triamcinolone

Triamcinolone is a long-acting corticosteroid with anti-inflammatory, anti-oedematous, anti-proliferative, anti-angiogenetic, immunomodulatory and neuroprotective effects through binding to glucocorticoid receptors. Triamcinolone can relieve several dermatitis, immune diseases and ocular diseases[1][2].

Product Specifications

CAS Number

[124-94-7]

UNSPSC

12352211

Hazard Statement

H351

Target

Glucocorticoid Receptor; Interleukin Related

Type

Natural Products

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Endocrinology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Triamcinolone.html

Concentration

10mM

Purity

99.86

Solubility

DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL

Smiles

F[C@@]1([C@]2(C=C3)C)[C@](CCC2=CC3=O)([H])[C@@](C[C@@H](O)[C@]4(O)C(CO)=O)([H])[C@]4(C)C[C@@H]1O

Molecular Formula

C21H27FO6

Molecular Weight

394.43

Precautions

H351

References & Citations

[1]McAlindon TE, et al. Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial. JAMA. 2017;317 (19) :1967-1975.|[2]Spandau UH, et al. Effect of triamcinolone acetonide on proliferation of retinal endothelial cells in vitro and in vivo. Br J Ophthalmol. 2005 Jun;89 (6) :745-7.