SF-22
SF-22 is a potent and brain-penetrant antagonist of neuropeptide Y receptor (Y2R), with the IC50 value of 750 nM. SF-22 plays an important role in neurological disease[1].
Product Specifications
CAS Number
[824981-55-7]
UNSPSC
12352005
Hazard Statement
H319
Target
Neuropeptide Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sf-22.html
Purity
99.49
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC=C1C2=CC=CC=C2)C3=CC=C(C)C(S(=O)(NC4=CC(C)=CC=C4C)=O)=C3
Molecular Formula
C28H26N2O3S
Molecular Weight
470.58
Precautions
P264-P280-P305+P351+P338
References & Citations
[1]P Brothers, et al. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screeningShaun. Mol Pharmacol. 2010 Jan;77 (1) :46-57.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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