Piperacillin

Piperacillin is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam[1][2][3].

Product Specifications

CAS Number

[61477-96-1]

Product Name Alternative

Pipracil

UNSPSC

12352005

Hazard Statement

H317, H334

Target

Antibiotic; Bacterial; Beta-lactamase; Penicillin-binding protein (PBP)

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/piperacillin.html

Concentration

10mM

Purity

98.37

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](NC(N3C(C(N(CC)CC3)=O)=O)=O)C4=CC=CC=C4)=O)N1C2=O)O

Molecular Formula

C23H27N5O7S

Molecular Weight

517.55

Precautions

H317, H334

References & Citations

[1]Fu KP, et al. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents Chemother. 1978, 13 (3) :358-67. |[2]Bodey GP, et al. Piperacillin: In Vitro Evaluation. Antimicrob Agents Chemother. 1978, 14 (1) :78-87.|[3]Harada Y, et al. In vitro and in vivo activities of piperacillin-tazobactam and meropenem at different inoculum sizes of ESBL-producing Klebsiella pneumoniae. Clin Microbiol Infect. 2014, 20 (11) :O831-9.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

β-lactam

Citation 01

Antimicrob Agents Chemother. 2023 Jun 15;67 (6) :e0160322.|Int J Antimicrob Agents. 2025 Jun 9:107551.|J Antimicrob Chemother. 2025 Nov 5:dkaf408.|medRxiv. 2025 Mar 13:2025.03.11.25323422.|Microbiol Spectr. 2023 Feb 14;11 (1) :e0303822.|Microbiol Spectr. 2023 Jun 15;11 (3) :e0069223.|Molecules. 2025 Mar 9;30 (6) :1224.|PLoS Pathog. 2024 Dec 31;20 (12) :e1012783.|Biomed Res Int. 2018 Jul 2:2018:3579832.|bioRxiv. 2024 May 10.|Nat Commun. 2022 Mar 2;13 (1) :1116.