Ac2-12

Ac2-12, an annexin/lipocortin 1 (LC1) -mimetic peptide, inhibit neutrophil extravasation. Ac2-12 has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models[1][2].

Product Specifications

CAS Number

[256447-08-2]

UNSPSC

12352209

Target

Annexin A

Type

Peptides

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac2-12.html

Purity

99.87

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

[Ac-AMVSEFLKQAW]

Molecular Formula

C63H94N14O17S

Molecular Weight

1351.57

References & Citations

[1]L H Lim, et al. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A. 1998 Nov 24;95 (24) :14535-9.|[2]M Perretti, et al. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol. 2001 Jun;158 (6) :1969-73.